SLC3A2

src: clincancerres.aacrjournals.org

4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene.

SLC3A2 comprises the heavy subunit of the large neutral amino acid transporter (LAT1) that is also known as CD98 (cluster of differentiation 98).

Video SLC3A2

Function

SLC3A2 is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha-amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

LAT1 is a heterodimeric membrane transport protein that preferentially transports neutral branched (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids. LAT is highly expressed in brain capillaries (which form the blood brain barrier) relative to other tissues.

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:

• 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene)
• CD98 light subunit protein encoded by the SLC7A5 gene

Maps SLC3A2

Interactions

SLC3A2 has been shown to interact with SLC7A7.

src: www.frontiersin.org

See also

• Heterodimeric amino acid transporter

src: www.pnas.org

References

src: www.ptgcn.com

Further reading

src: www.researchgate.net

External links

• Large Neutral Amino Acid-Transporter 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
• Amino Acid Transport System L at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Source of article : Wikipedia